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Biological Mechanisms and Clinical Challenges of Platelet-Rich Plasma in Chronic Musculoskeletal Pain: From
Haizhou Zhou1, Qianjie Huang2, Yichao Chen1
1Department of Painology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, 201700, People's Republic of China.
Background:
Chronic musculoskeletal pain (CMP) affects over 1 billion people globally. Platelet-rich plasma (PRP) therapy has emerged as a promising regenerative approach.
Methods:
This review synthesizes current literature on PRP's biological mechanisms, preparation techniques, clinical efficacy, and ethical challenges, with a focus on multi-omics integration for personalized therapy.
Results:
PRP promotes tissue repair through growth factor release and immunomodulation, but clinical translation is hampered by preparation variability, lack of predictive biomarkers, and ethical concerns. Multi-omics approaches (genomics, proteomics, metabolomics) offer potential for efficacy prediction and treatment personalization.
Conclusion:
Standardization of PRP preparation and rigorous long-term trials are urgently needed. Multi-omics-guided strategies may enhance precision in PRP therapy for CMP.
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