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Related Experiment Video

Updated: Jan 11, 2026

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
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Exercise-Based Pain Interventions for People with Dementia Using a Biopsychosocial-Environmental (BPSE) Model.

Annalisa Na1, Joke Bradt1, G Peter Gliebus2

  • 1Drexel University, Philadelphia, 60 N. 36th Street, PA 19104 USA.

Current Geriatrics Reports
|November 13, 2025
PubMed
Summary

The Biopsychosocial-Environmental (BPSE) model helps manage knee osteoarthritis pain in people with dementia. This approach tailors exercise interventions to improve their quality of life.

Keywords:
AgingComorbidityDementiaExerciseMobilityPain

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Area of Science:

  • Gerontology
  • Neuroscience
  • Rehabilitation Medicine

Background:

  • Knee osteoarthritis (OA) pain and dementia-related neurodegeneration interact across biological, psychological, social, and environmental factors.
  • These interacting factors negatively impact function and quality of life in people living with dementia (PLWD).
  • Existing research highlights the complex interplay between OA pain and dementia.

Purpose of the Study:

  • To introduce the Biopsychosocial-Environmental (BPSE) model for guiding exercise interventions.
  • To address knee OA pain in people living with dementia (PLWD).
  • To synthesize literature on OA pain, dementia, and exercise, and demonstrate the BPSE model's clinical utility.

Main Methods:

  • Literature synthesis on biological, psychological, social, and environmental aspects of knee OA pain in PLWD.
  • Review of neurodegeneration in PLWD and exercise implications.
  • Demonstration of the BPSE model for designing tailored exercise interventions.

Main Results:

  • Knee OA pain and dementia interact through multiple interconnected factors.
  • These interactions exacerbate functional limitations and reduce quality of life.
  • The BPSE model offers a framework to address these complex interactions.

Conclusions:

  • The BPSE model provides a structured approach to tailor exercise interventions for PLWD with knee OA.
  • Applying the BPSE model can potentially improve pain management, mobility, and quality of life.
  • This model can inform future chronic disease management strategies for PLWD.