Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Electron Microscope Tomography and Single-particle Reconstruction

Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Single twistable tendon-driven continuum robots.

Nature communications·2026

Same author

ESD-VesNet: uncertainty-aware vessel segmentation network for endoscopic submucosal dissection with hard negative mining.

International journal of computer assisted radiology and surgery·2026

Same author

Distribution and rate of lymph node metastasis following neoadjuvant chemoimmunotherapy in non-small cell lung cancer.

BMC cancer·2026

Same author

ASO Visual Abstract: The Surgical Outcomes of Brachiocephalic Vein Transection versus Reconstruction for Locally Advanced Thymic Epithelial Tumors.

Annals of surgical oncology·2026

Same author

ASO Author Reflections: Transection or Reconstruction? Surgical Decision-Making for Brachiocephalic Vein Involvement in Locally Advanced Thymic Epithelial Tumors.

Annals of surgical oncology·2026

Same author

The Surgical Outcomes of Brachiocephalic Vein Transection Versus Reconstruction for Locally Advanced Thymic Epithelial Tumors.

Annals of surgical oncology·2026

Search research articles

Related Experiment Video

Updated: Jan 11, 2026

Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin

Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin

Published on: March 14, 2018

Bimodal Tactile Tomography with Bayesian Sequential Palpation for Intracavitary Microstructure Profiling and

Wenchao Yue¹, Chao Xu², Tao Zhang¹

¹Department of Electronic Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.

Cyborg and Bionic Systems (Washington, D.C.)

|November 13, 2025

Summary

This study introduces a novel robotic palpation technique using ElastoSight for real-time tissue evaluation. The method precisely locates and segments lesions, enhancing disease diagnosis in minimally invasive surgery.

More Related Videos

Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach

Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach

Published on: April 25, 2025

Multimodal Hierarchical Imaging of Serial Sections for Finding Specific Cellular Targets within Large Volumes

Multimodal Hierarchical Imaging of Serial Sections for Finding Specific Cellular Targets within Large Volumes

Published on: March 20, 2018

Related Experiment Videos

Last Updated: Jan 11, 2026

Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin

Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin

Published on: March 14, 2018

Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach

Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach

Published on: April 25, 2025

Multimodal Hierarchical Imaging of Serial Sections for Finding Specific Cellular Targets within Large Volumes

Multimodal Hierarchical Imaging of Serial Sections for Finding Specific Cellular Targets within Large Volumes

Published on: March 20, 2018

Area of Science:

Medical Robotics
Surgical Technology
Biomedical Engineering

Background:

Robotic palpation is vital for in situ tissue biomechanical evaluation in diagnosing diseases, particularly in luminal organs.
Current surgical robotic systems lack tactile intelligence for comprehensive tissue assessment, hindering abnormality detection.
Optical coherence tomography offers 3D visualization but lacks tactile sensing for lesion profiling.

Purpose of the Study:

To develop a robotic bimodal palpation technique for precise, real-time tissue biomechanical evaluation.
To integrate optical coherence tomography-based tactile sensing for enhanced lesion detection and boundary identification.
To improve abnormality detection and surgical precision in robot-assisted minimally invasive procedures.

Main Methods:

Development of a robotic bimodal palpation technique utilizing the ElastoSight optical coherence tomography-based tactile sensor.
Implementation of circumferential and sliding B-scan modes combined with Bayesian optimization.
Validation using tumor phantom models for lesion localization and segmentation accuracy.

Main Results:

Achieved tumor localization within 30 iterations, with F1 scores > 0.976 and centroid error < 0.032 mm in phantom models.
Demonstrated accurate segmentation of hard tissue inclusions with a precision rate of 0.983 and area error < 0.25 mm² using sliding B-scan mode.
The technique effectively addressed real-time lesion localization and segmentation challenges in simulations and experiments.

Conclusions:

The proposed robotic bimodal palpation technique significantly enhances real-time lesion localization and segmentation capabilities.
This approach has the potential to improve the precision and efficiency of abnormality detection in robot-assisted minimally invasive surgery.
The ElastoSight sensor integrated into this technique shows promise for advancing tissue assessment during procedures like tumor removal.