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Related Experiment Video

Updated: Jan 11, 2026

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines
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In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

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DNA-programmed cell assembly: from cells, tissues to organoids.

Zhenyi Chen1,2, Pan Fu2, Kaizhe Wang2

  • 1School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, China.

Frontiers in Bioengineering and Biotechnology
|November 13, 2025
PubMed
Summary

DNA nanotechnology offers a novel approach to precisely organize cells for tissue engineering. This review highlights DNA

Keywords:
DNA nanomaterialscell assemblycell engineeringcell-cell interactionsorganoidstissue models

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Area of Science:

  • Biotechnology and Bioengineering
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Precise spatial organization of cells into functional tissues is crucial for biology and regenerative medicine.
  • Current cell assembly methods lack specificity, reproducibility, and dynamic control for mimicking native tissue architectures.

Purpose of the Study:

  • To explore the use of DNA as a programmable and biocompatible strategy for engineering cell-cell interactions.
  • To review advances in constructing hierarchically ordered tissue models using DNA nanotechnology.

Main Methods:

  • Introduction to DNA toolbox properties and strategies for cell modification and assembly.
  • Highlighting research on DNA-encoded cell spheroids, layered tissues, and organoids.

Main Results:

  • DNA nanotechnology enables precise control over cell-cell interactions and tissue self-assembly.
  • Demonstrated success in creating complex 3D tissue models like spheroids, layered tissues, and organoids.

Conclusions:

  • DNA-programmed assembly presents a promising strategy for advanced tissue engineering.
  • Identified current challenges and future research directions in DNA-based tissue construction.