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Isolated Small Fiber Neuropathy and Chemotherapy-Associated Cognitive Dysfunction Following Treatment for Gastric

Haneen A Salama1, Muhammad Umair2, Isabella R Rojas3

  • 1Faculty of Medicine, University of Benghazi, Benghazi, LBY.

Cureus
|November 13, 2025
PubMed

Insights

Small fiber neuropathy (SFN) is an overlooked complication in cancer patients, often masked by chemotherapy-induced cognitive impairment. Autonomic testing is crucial for diagnosing SFN in survivors with unexplained symptoms.

Area of Science:

  • Neurology
  • Oncology
  • Neurotoxicology

Background:

  • Small fiber neuropathy (SFN) is an underdiagnosed complication in cancer patients.
  • Chemotherapy-induced cognitive impairment, or 'chemobrain,' complicates diagnosis.
  • Awareness and specific testing for SFN are often lacking.
Keywords:
c-fiber dysfunctionchemobrainchemotherapy-induced neurotoxicityemg-negative neuropathyflotgastric adenocarcinomasfnsmall fiber neuropathysudoscan

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