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Dual-regulatory miRNAs: master regulators and therapeutic targets in bone-metastatic breast cancer

Feifei Meng1, Mengdi Zhang1, Dongqing Pu2

  • 1College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.

Frontiers in Molecular Biosciences
|November 13, 2025
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in breast cancer bone metastasis, acting as either oncogenic or tumor suppressors. Understanding their mechanisms offers new diagnostic and therapeutic strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer bone metastasis involves complex transcriptional and cellular changes.
  • Current treatments are largely palliative, highlighting the need for novel therapeutic targets.
  • MicroRNAs (miRNAs) are crucial regulators of gene expression with established roles in cancer.

Purpose of the Study:

  • To systematically review the regulatory roles of miRNAs in breast cancer bone metastasis.
  • To analyze the mechanisms of action for critical miRNAs and their target genes.
  • To identify potential miRNA biomarkers and therapeutic targets for early diagnosis and treatment.

Main Methods:

  • Literature review of studies on miRNAs in breast cancer bone metastasis.
  • Analysis of miRNA regulatory networks and target gene interactions.
  • Synthesis of current knowledge on oncogenic miRNAs (oncomiRs) and tumor suppressor miRNAs (tsmiRs).

Main Results:

  • miRNAs play pivotal roles in regulating gene expression during breast cancer bone metastasis.
  • Specific miRNAs can act as oncomiRs or tsmiRs, influencing disease progression.
  • miRNAs demonstrate potential as biomarkers for diagnosis and prognosis.

Conclusions:

  • miRNAs are critical regulators in breast cancer bone metastasis.
  • Targeting specific miRNAs offers promising avenues for novel therapeutic strategies.
  • Further research into miRNA mechanisms can advance early diagnosis and treatment.
Keywords:
bone metastasisbone microenvironmentbreast cancermiRNAstargeted therapy

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