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Published on: September 15, 2017
Co-Occurrence of Endogenous and Exogenous Cushing's Syndromes: Does "Double Cushing Syndrome" Really Exist? A Case
Reza Amani-Beni1, Atiyeh Karimi Shervedani2, Bahar Darouei1
1Heart Failure Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran.
Abstract:
Double Cushing syndrome exists: exogenous steroid use can mask concurrent adrenal hypercortisolism. When symptoms persist and cortisol remains high after tapering or stopping prescribed glucocorticoids, an endogenous source is likely. Early recognition with ACTH testing, dexamethasone suppression, and adrenal imaging reduces misdiagnosis, favors timely surgery, and supports safe tapering.
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