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L-Theanine Mitigates Aβ1-42-Induced Apoptosis in SH-SY5Y Cells
Yuwei Chen1,2, Zhendong Wang1, Jieying Wang1
1Institute for Research on Health Information and Technology, School of Public Health Xi'an Medical University Xi'an China.
Food Science & Nutrition
|November 13, 2025
Summary
L-theanine, a compound in tea, effectively prevents Alzheimer's disease (AD) cell death. It works by reducing oxidative stress and maintaining mitochondrial function in brain cells, offering a natural approach to AD prevention.
Area of Science:
- Neuroscience
- Pharmacology
- Nutritional Science
Background:
- Alzheimer's disease (AD) is a neurodegenerative disorder linked to neuronal apoptosis.
- Natural plant compounds are increasingly researched for AD prevention.
- L-theanine, found in tea, shows potential neuroprotective effects.
Purpose of the Study:
- To investigate L-theanine's effect on Amyloid-beta (1-42) induced apoptosis in SH-SY5Y cells.
- To explore the mechanisms behind L-theanine's neuroprotective action.
- To provide a theoretical basis for using L-theanine in AD intervention and prevention.
Main Methods:
- An in vitro Alzheimer's disease model using SH-SY5Y cells.
- Induction of apoptosis using Amyloid-beta (1-42).
- Assessment of L-theanine's impact on apoptosis, oxidative stress, and mitochondrial function.
Main Results:
- L-theanine significantly inhibited Amyloid-beta (1-42)-induced apoptosis in SH-SY5Y cells.
- L-theanine suppressed oxidative stress markers.
- L-theanine helped preserve mitochondrial function.
Conclusions:
- L-theanine demonstrates efficacy in preventing apoptosis in an in vitro AD model.
- Mechanisms involve mitigating oxidative stress and maintaining mitochondrial health.
- L-theanine presents a promising natural compound for Alzheimer's disease intervention.
