Management of sickle cell disease in pregnancy

Area of Science:

• Hematology
• Obstetrics
• Genetics

Background:

• Sickle cell disease (SCD) is the most prevalent inherited blood disorder.
• SCD involves red blood cell sickling, leading to hemolysis and vaso-occlusion.
• This causes widespread organ damage and complications.

Purpose of the Study:

• To highlight the increased risks associated with pregnancy in women with SCD.
• To emphasize the need for specialized care for pregnant patients with SCD.
• To underscore the importance of multidisciplinary management.

Main Methods:

• This is a review/summary of existing knowledge on SCD in pregnancy.
• Focuses on the pathophysiology and clinical implications.
• Highlights evidence-based recommendations for care.

Main Results:

• Pregnant individuals with SCD face higher risks of organ dysfunction.
• SCD-specific complications during pregnancy are common.
• Adverse maternal and fetal outcomes are significantly elevated.

Conclusions:

• Pregnancy in SCD patients is high-risk, demanding specialized care.
• Multidisciplinary teams are essential for optimal management.
• Early intervention and expert care can mitigate complications.