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Updated: Jan 11, 2026

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Ocular Blood Velocity Measurement With Optical Coherence Tomography Using Speckle Analysis.

Richard F Spaide¹, Kyungmoo Lee², Jen-Wei Kuo²

¹Vitreous Retina Macula Consultants of New York, New York, NY, USA.

Translational Vision Science & Technology

|November 13, 2025

Summary

This summary is machine-generated.

A new optical coherence tomography (OCT) method quantifies ocular blood flow velocity using speckle pattern analysis. This non-invasive technique accurately measures flow and aids in diagnosing vascular diseases.

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Area of Science:

Ophthalmology
Biomedical Optics
Medical Imaging

Background:

Accurate quantification of ocular blood flow velocity is crucial for diagnosing and monitoring various eye diseases.
Current methods for measuring ocular hemodynamics may have limitations in terms of invasiveness, resolution, or computational demands.

Purpose of the Study:

To develop and validate a novel method for quantifying blood flow velocity in ocular vessels.
To utilize speckle pattern analysis in optical coherence tomography (OCT) images for this purpose.

Main Methods:

Developed an OCT-based methodology analyzing speckle structures to derive a relative flow value (RFV).
Evaluated the method using a model eye with controlled flow rates of human and porcine blood.
Assessed correlation between RFV and actual flow velocities, and measurement consistency across varying vessel sectioning angles.

Main Results:

RFV showed a strong power-law relationship with actual flow velocities (r2 = 0.983), accurate up to 70 mm/s.
Measurements remained consistent across different vessel sectioning angles.
Demonstrated detection of altered pulsatility and reduced venous flow in a patient with central retinal vein occlusion.

Conclusions:

The speckle-based OCT method offers a non-invasive, depth-resolved approach for quantifying ocular blood velocity.
The technique has minimal computational requirements and potential for diagnosing/monitoring ocular and systemic vascular abnormalities.
Further validation across diverse patient populations is recommended.