Induction of helical chirality in tetrahedral transition metal complexes with non-bridging monodentate oxazolines
Marija Bakija1, Berislav Perić1, Tamara Rinkovec1
1Ruđer Bošković Institute, Bijenička c. 54, HR-10000 Zagreb, Croatia. Srecko.Kirin@irb.hr.
Abstract:
Chirality on C4-atoms of non-bridging monodentate oxazolines direct stereoselective formation of helical chirality in [M(1)2X2] tetrahedral metal complexes of zinc(II), cadmium(II) and cobalt(II) halides, as revealed by their crystal structures. This feature was used to prepare a set of helically chiral derivatives with various structural motifs. In particular, bulkiness, non-covalent interactions and choice of point chirality combinations were found to strongly affect induction of chirality on the metal atom. The substituent influence on complexation and chiral induction was analyzed using XRD-diffraction studies, NMR, UV-Vis and CD spectroscopies, as well as DFT calculations.
More Related Videos
04:51Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
Published on: June 23, 2023
10:17Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Related Concept Videos
Stereoisomerism
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Coordination Number and Geometry
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
Complexation Equilibria: The Chelate Effect
Chirality at Nitrogen, Phosphorus, and Sulfur
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
