Multivariate 25-Year Trend Analysis of Mortality Due to Liver Hydatid Cysts

In this restrospective and cross-sectional study, it was aimed to analyze the time-dependent change in mortality due to liver hydatid cysts in a multicenter and multivariate manner over 25 years.

In the study, 213 files of patients with liver Hydatid cysts underwent surgery in multicenter between 1993 and 2018 were retrospectively included. The mortality rate in patients was reported as 11.7%. Gender, age, cyst stage, number of cysts, localization, maximum cyst diameter, latex and albendazole use, comorbidity, early and late complications, mortality, hospitalization and follow-up periods of the patients were analyzed.

Age mean, right localization and cardiovascular disease (CVD) frequency parameters were significantly higher in mortality group (p < 0.05). Follow up duration was significantly higher in living group (p < 0.05). Mortality was significantly correlated with age (r = 0.375; p < 0.01), localization (r = - 0.153; p < 0.05), CVD (r = 0.264; p < 0.01) and follow up duration (r = - 0.262; p < 0.01). According to year controlled partial correlation analysis, mortality was only significantly correlated with age (r = 0.301; p < 0.05). Cox regression analysis results showed that effects of age (B = 0.093; p < 0.01), right localization (B = 2.215; p < 0.05) and left localization (B = 2.704; p < 0.05) on mortality were significant. Survival function for mortality showed that about first 100 days after surgery were important for mortality. After 200 day, cumulative survival trend was more stable than before. In left localized cyst, about first 500 days after surgery is important for mortality. In right and segment localized patients, first 1000 days after surgery is important for mortality.

According to the results of multicenter and 25-year experience in patients with hydatid cysts, the causes of mortality did not change significantly over time, and only age and localization were found to be important factors. Although there have been improvements in environmental hygiene and risk factors over time, their effects on disease-related mortality were found to be insignificant.