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Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

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Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
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Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
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Updated: Jan 6, 2026

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RAG-Enhanced Open SLMs for Hypertension Management Chatbots.

Gianluca Aguzzi1, Matteo Magnini1, Aqila Farahmand2

  • 1Department of Computer Science and Engineering, University of Bologna, Cesena, Italy.

Journal of Medical Systems
|November 13, 2025
PubMed
Summary
This summary is machine-generated.

We developed a privacy-focused chatbot for hypertension management using open-source small language models (SLMs) on personal devices. Retrieval-Augmented Generation (RAG) with SLMs enhances accuracy, though newer models show promise without it.

Keywords:
Chronic disease self-managementHypertensionLarge language modelsRetrieval-augmented generation

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Area of Science:

  • Digital Health
  • Artificial Intelligence in Healthcare
  • Computational Linguistics

Background:

  • Chronic disease management necessitates continuous patient support and monitoring.
  • Chatbots offer a scalable solution for patient engagement and assistance in home-based healthcare.
  • Large language models (LLMs) present privacy and computational challenges for widespread deployment.

Purpose of the Study:

  • To develop a privacy-preserving chatbot for hypertensive patients using open-source small language models (SLMs).
  • To enable chatbot deployment on resource-constrained personal devices for continuous patient support.
  • To evaluate the effectiveness of retrieval-augmented generation (RAG) with SLMs for question-answering (QA) tasks.

Main Methods:

  • Developed a chatbot utilizing open-source SLMs for deployment on personal devices.
  • Implemented retrieval-augmented generation (RAG) with a local knowledge base to enhance conversational performance and ensure data privacy.
  • Experimented with eight SLMs, two prompt configurations, and various RAG strategies (embedding and retrieval).
  • Evaluated chatbot performance using reference metrics and expert assessment.

Main Results:

  • Retrieval-augmented generation (RAG) enhanced SLMs demonstrated improved response clarity and content accuracy in QA tasks.
  • Newer SLMs, such as Qwen3, exhibited strong performance even without RAG, indicating potential for simplified future implementations.
  • The developed chatbot achieved competitive accuracy with low computational costs suitable for end-user devices.

Conclusions:

  • SLM-based chatbots, particularly when enhanced with RAG, offer a viable and privacy-conscious solution for chronic disease management.
  • The evolution of SLMs may reduce the reliance on complex retrieval mechanisms for achieving high performance.
  • This approach facilitates accessible, continuous patient support for hypertension management on personal devices.