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Updated: Jan 6, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Endosomal Mechanisms in Heart Failure Pathophysiology.

Martijn F Hoes1,2,3, Shujin Wang4,5, Joost Jfp Luiken6,7,8

  • 1Department of Cardiology, Maastricht University Medical Center+, Maastricht, the Netherlands.

Current Heart Failure Reports
|November 13, 2025
PubMed
Summary

Endosomal dysfunction contributes to heart failure by disrupting cardiac metabolism and causing lipotoxicity. Targeting the endosomal system offers a promising therapeutic strategy for heart failure patients.

Keywords:
CD36Cardiac metabolismEndosomal functionv-ATPase

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