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Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
Published on: April 28, 2023
Copper-Induced Nephropathy: Clinical Characterization of 36 Cases and Comprehensive Literature Review
Yi-Ling Li1,2, Jing Chen1,2, Jin-Rong Zhang3
1Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Abstract:
The etiology of chronic kidney disease (CKD) is complex, with environmental copper exposure emerging as a non-traditional risk factor whose nephrotoxic mechanisms and impacts require in-depth investigation. This study conducted a retrospective analysis of 36 patients with abnormally elevated urinary copper levels, evaluating their clinical manifestations, biochemical indicators, and responses following copper chelation therapy, along with a literature review to explore the relationship between copper levels and renal injury. The results demonstrated a significant correlation between urinary copper content and the severity of renal dysfunction (P < 0.001). After treatment, improvements were observed in renal function (BUA P = 0.046), liver function (ALT P = 0.013), and anemia indicators (HGB P = 0.034). These findings indicate that abnormal urinary copper is a risk factor for kidney injury.
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