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Association of Choroid Plexus Dysfunction and Cognitive Decline in Preeclampsia: Using T1WI Imaging, Quantitative
Boyao Chen1, Meng Li2,3, Linfeng Yang4
1Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Human Brain Mapping
|November 13, 2025
Summary
Preeclampsia is linked to smaller choroid plexus volume (CPV) and higher susceptibility values, potentially aiding in early diagnosis and identifying cognitive decline in pregnant individuals.
Area of Science:
- Neurology
- Radiology
- Obstetrics
Background:
- Preeclampsia is a severe pregnancy complication associated with potential brain injury.
- Early detection of cognitive deficits in preeclampsia remains a clinical challenge.
Purpose of the Study:
- To investigate alterations in choroid plexus volume (CPV) and susceptibility values of the choroid plexus (ChP) using quantitative susceptibility mapping (QSM) in preeclampsia patients.
- To assess the diagnostic performance of CPV and ChP susceptibility values for preeclampsia and related cognitive decline.
Main Methods:
- Recruited 281 participants: 98 nonpregnant healthy controls (NPHC), 85 pregnant healthy controls (PHC), and 98 preeclampsia patients.
- Utilized 1.5T MR scanner for imaging, collecting clinical and cognitive test data.
- Employed one-way ANOVA, multiple linear regression, and receiver operating characteristic (ROC) analysis.
Main Results:
- Preeclampsia patients showed significantly smaller CPV and higher ChP susceptibility values compared to controls (p < 0.001).
- CPV and ChP susceptibility values correlated with BMI, mean arterial pressure, and hemoglobin.
- CPV/eTIV and ChP susceptibility values were independent factors influencing cognitive decline (TMT scores).
Conclusions:
- Smaller CPV and higher ChP susceptibility values are characteristic of preeclampsia.
- These imaging measures, combined with clinical factors, can help distinguish preeclampsia and identify cognitive decline.
- CPV and ChP susceptibility values may serve as auxiliary diagnostic indices for preeclampsia and associated cognitive deficits.
