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Updated: Jan 11, 2026

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
Published on: February 25, 2016
Demethyltorosaflavone C from Cassia nomame inhibits nitric oxide production
Daiki Nagatsuka1, Tetsuya Saito2, Makoto Fujisawa1,2
1Graduate School of Food and Nutritional Sciences, Toyo University, Asaka, Saitama, Japan.
Abstract:
In RAW264 macrophages, demethyltorosaflavone C (DTFC)-luteolin derivative from Cassia nomame-suppressed lipopolysaccharide-induced nitric oxide production without cytotoxicity. DTFC exhibited no nitric oxide radical scavenging activity but downregulated inducible nitric oxide synthase and cyclooxygenase-2 at protein and mRNA levels, indicating anti-inflammatory effects through pathways similar to those of luteolin. These results suggest that DTFC appears to have potential comparable to luteolin.
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