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The Importance of Treatment Timing and Positioning in IBD
Giulia Valdiserra1, Massimo C Fantini2,3, Agnese Favale2,3
1Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
None:
This commentary examines the progressive decline in biologic efficacy in inflammatory bowel disease, highlighting pharmacologic, immunologic, and cellular mechanisms of resistance. It advocates for early, biomarker-guided, and mechanistically informed sequencing to preserve long-term therapeutic response and overcome the emerging "therapeutic ceiling."
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