Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

954
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
954

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-Inflammatory Effects of Progesterone on Human Microglia via TLR4/NLRP3 Pathway Modulation: Relevance to Drug-Resistant Epilepsy.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Understanding Online Health Information Consumption Through Web Analytics of the Italian Society of Pharmacology Magazine: 3-Year Descriptive Analysis.

JMIR formative research·2026
Same author

Is the Occurrence of Bradycardia During Percutaneous Balloon Compression for Trigeminal Neuralgia a Clinical Prognostic Indicator?

World neurosurgery·2026
Same author

Increased Pre-Activation and Co-Contraction in ACL-Reconstructed Athletes: Insights from AI-based EMG Analysis.

Medicine and science in sports and exercise·2026
Same author

Muscle Network of Parkinson's Gait: A 12-Month Longitudinal Analysis Before and After Deep Brain Stimulation Surgery.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same author

Temporal stem anatomy. Photorealistic surface scanning anatomical and 3D tractography study.

Journal of neurological surgery. Part A, Central European neurosurgery·2026
Same journal

Transfer Learning with Simulated and Recorded Data Improves Predictions of Lateral Pinch Thumb-Tip Forces.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same journal

Sensing Muscle Deformation for Upper-Limb Prosthetic Control: a Narrative Review.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same journal

Entropy-Based Graph Learning Framework for Cross-Subject Detection of Electrical Status Epilepticus During Sleep (ESES).

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same journal

Touch-related electrophysiology activity promotes human movements initiation.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same journal

Ultrasound-Informed State Estimation of Wrist Tremor Dynamics via Koopman Operator for Personalized Sensory Peripheral Nerve Stimulation.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same journal

Motion Intention Recognition and DDPG-Based Adaptive Impedance Control for a Robotic Upper-Limb Exoskeleton.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
See all related articles

Related Experiment Video

Updated: Jan 11, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

23.0K

Improved Dual-Task Interference in Parkinson's Disease Following Deep Brain Stimulation.

Marco Ghislieri, Lorenzo Locoratolo, Fabrizio Sciscenti

    IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
    |November 13, 2025
    PubMed
    Summary
    This summary is machine-generated.

    Deep Brain Stimulation (DBS) improves dual-tasking in Parkinson's Disease (PD) patients by enhancing attentional allocation. Post-surgery, PD patients show better motor-cognitive performance, reducing fall risk.

    More Related Videos

    Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
    12:04

    Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

    Published on: January 6, 2011

    13.4K
    A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
    07:14

    A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

    Published on: May 31, 2016

    15.3K

    Related Experiment Videos

    Last Updated: Jan 11, 2026

    Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
    11:12

    Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

    Published on: July 16, 2014

    23.0K
    Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
    12:04

    Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

    Published on: January 6, 2011

    13.4K
    A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
    07:14

    A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

    Published on: May 31, 2016

    15.3K

    Area of Science:

    • Neuroscience
    • Neurology
    • Rehabilitation Medicine

    Background:

    • Parkinson's Disease (PD) significantly impairs motor and cognitive functions, particularly during dual-tasking.
    • Dual-task interference in PD patients often results in a
    • posture-second
    • strategy, affecting attentional resource management.

    Purpose of the Study:

    • To evaluate the impact of Deep Brain Stimulation (DBS) on motor-cognitive dual-task performance in Parkinson's Disease (PD) patients.
    • To analyze changes in muscle synergies and Dual Task Effect (DTE) pre- and post-DBS surgery.

    Main Methods:

    • Muscle synergies of 27 PD patients were analyzed at three time points (pre-surgery, 3 months, 12 months post-surgery).
    • A control group of 30 age-matched individuals was included for comparison.
    • Motor and cognitive metrics, including mDTEFWHM and cDTE, were assessed during walking and a motor-cognitive dual task.

    Main Results:

    • DBS significantly enhanced dual-task capacity in PD patients, indicated by improved motor DTE (mDTEFWHM).
    • PD patients transitioned from a detrimental
    • posture-second
    • strategy to more efficient attentional allocation post-DBS.
    • Cognitive DTE (cDTE) remained stable and comparable to controls, showing no significant change after DBS.

    Conclusions:

    • DBS enhances attentional resource management in PD patients, improving their ability to handle cognitive load during motor tasks.
    • The findings suggest that DBS may lead to improved dynamic balance and reduced fall risk in daily activities for PD patients.