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Updated: Jan 11, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Advances in Diagnosis, Prognosis, and Treatment of Renal Cell Carcinoma
Stefania Ferretti1, Natali Rodriguez Peñaranda2, Stefano Puliatti2
1Department of Urology, AOU di Modena, Modena, Italy.
Abstract:
Renal cell carcinoma (RCC) remains a biologically heterogeneous malignancy with evolving therapeutic paradigms. Over the past two decades, advances in systemic therapies, surgical techniques, and local treatments have improved outcomes, yet challenges remain in predicting outcomes, tailoring treatment to risk, and treatment integration. This Special Collection, Renal Cell Carcinoma-From Genetics to Oncological and Surgical Treatments: New Insights, highlights recent innovations across these domains. Contributions include validation of prognostic tools such as the G8 geriatric screening and GRANT scores, exploration of stereotactic body radiotherapy for oligometastatic disease, and the emerging role of exosomes as biomarkers and therapeutic vehicles. Together, these findings underscore the importance of integrating molecular profiling, real-world data, and technological advances to guide personalized RCC management, with the ultimate aim of improving survival while preserving quality of life.
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