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Updated: Jan 11, 2026

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
Published on: September 2, 2015
Numerical study on thermo-mechanical interaction in skin tissue with temperature-dependent properties under
Yingze Wang1, Zhaowei He1, Sheng Zhang1
1School of Energy and Power Engineering, Jiangsu University, Zhenjiang, 212013, PR China.
Cryogen spray cooling combined with pulsed laser irradiation treats deep skin lesions. This study models the thermo-mechanical response, finding cryogen spray cooling reduces epidermal damage but increases compressive stress, necessitating balanced treatment protocols.
Area of Science:
- Biomedical Engineering
- Computational Biology
- Dermatology
Background:
- Pulsed laser irradiation and cryogen spray cooling (CSC) show promise for treating deep skin lesions like port wine stains (PWS).
- Optimizing this combined therapy requires understanding the complex thermo-mechanical behavior of skin under sequential thermal stresses.
- Existing models may not fully capture the dynamic responses influenced by temperature-dependent properties and advanced heat transfer mechanisms.
Purpose of the Study:
- To develop and validate a comprehensive bio-thermo-mechanical coupling model for skin tissue.
- To investigate the dynamic thermo-mechanical responses and thermal damage in multi-layered skin under pulsed laser and CSC treatment.
- To analyze the influence of temperature-dependent properties and laser parameters on treatment outcomes.
Main Methods:
- Development of a coupled bio-thermo-mechanical model incorporating temperature-dependent material properties.
- Implementation of the dual-phase lag (DPL) bioheat transfer model to simulate heat transport.
- Numerical solution using the finite difference method to predict temperature, displacement, stress, and thermal damage distributions.
- Comparative analysis of simulation results under varying conditions and parameters.
Main Results:
- The model accurately predicts temperature, displacement, thermal stress, and damage distributions in layered skin.
- Temperature-dependent properties and laser parameters significantly impact the thermo-mechanical response.
- Cryogen spray cooling (CSC) effectively mitigates epidermal thermal damage.
- CSC application induces significant compressive stress in the skin tissue.
Conclusions:
- The developed model provides crucial insights into the bio-thermo-mechanical effects of combined laser and CSC treatments.
- Cryogen spray cooling offers a protective effect against epidermal damage but introduces mechanical stress.
- Balanced clinical protocols are essential to optimize efficacy and minimize adverse effects in treating deep skin lesions.
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