Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.6K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.6K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

83.4K
Overview
83.4K
Humoral Immune Responses01:36

Humoral Immune Responses

83.3K
Overview
83.3K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

271
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
271
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.7K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.7K
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

2.1K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MicroMap: a network visualisation resource for human microbiome metabolism.

NPJ biofilms and microbiomes·2025
Same author

From the 'Deep South' to adaptation for all Aotearoa: reflecting on ten years of the Deep South National Science Challenge.

Journal of the Royal Society of New Zealand·2025
Same author

Clinical phenotype and pathophysiological mechanisms underlying qualitative low VWF.

Blood·2025
Same author

Trained immunity causes myeloid cell hypercoagulability.

Science advances·2025
Same author

The MicroMap is a network visualisation resource for microbiome metabolism.

bioRxiv : the preprint server for biology·2025
Same author

Tissue factor-dependent colitogenic CD4<sup>+</sup> T cell thrombogenicity is regulated by activated protein C signalling.

Nature communications·2025
Same journal

Bridging the Gap in Laboratory Monitoring of Extended Half-Life Factor VIII and IX: Can Thrombin Generation Assays Overcome Assay Discrepancies?

Seminars in thrombosis and hemostasis·2026
Same journal

External Quality Assessment for Low Molecular Weight Heparin Monitoring in the Australasia/Asia-Pacific Region.

Seminars in thrombosis and hemostasis·2026
Same journal

Human evolution: between hemorrhage and thrombosis.

Seminars in thrombosis and hemostasis·2026
Same journal

Full- vs Reduced-Dose Direct Oral Anticoagulants for Extended Treatment of Cancer-Associated Thrombosis: A Multicenter Retrospective Cohort Study.

Seminars in thrombosis and hemostasis·2026
Same journal

Too Old for PESI?: Risk Stratification of Octogenarians with Pulmonary Embolism in the Emergency Department.

Seminars in thrombosis and hemostasis·2026
Same journal

Acute Management and Bleeding Outcomes in Pediatric Pulmonary Embolism: A Large Single-Center Retrospective Cohort Study.

Seminars in thrombosis and hemostasis·2026
See all related articles

Related Experiment Video

Updated: Jan 11, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.6K

Adaptive Immunity in Immunothrombosis.

David Noone1, Roger J S Preston1, Gemma Leon1

  • 1Irish Centre of Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

Seminars in Thrombosis and Hemostasis
|November 13, 2025
PubMed
Summary
This summary is machine-generated.

Adaptive immune cells play a key role in immunothrombosis, a process linking immune and coagulation systems. This review explores their involvement in various diseases, including autoimmune, allergic, and infectious conditions.

More Related Videos

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

14.8K
A Novel In vitro Model for Studying the Interactions Between Human Whole Blood and Endothelium
06:27

A Novel In vitro Model for Studying the Interactions Between Human Whole Blood and Endothelium

Published on: November 21, 2014

9.9K

Related Experiment Videos

Last Updated: Jan 11, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.6K
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

14.8K
A Novel In vitro Model for Studying the Interactions Between Human Whole Blood and Endothelium
06:27

A Novel In vitro Model for Studying the Interactions Between Human Whole Blood and Endothelium

Published on: November 21, 2014

9.9K

Area of Science:

  • Immunology
  • Hematology
  • Pathophysiology

Background:

  • Thrombosis is a common comorbidity in autoimmune, allergic, and infectious diseases, but the underlying mechanisms are not fully understood.
  • Immunothrombosis, the interplay between immune and coagulation systems, is crucial for injury response and pathogen clearance.
  • Emerging evidence highlights the significant role of adaptive immune cells in immunothrombosis, expanding beyond the traditional focus on innate immunity.

Purpose of the Study:

  • To review the involvement of adaptive immune cells in clot formation and resolution.
  • To explore how the adaptive immune system influences procoagulant activity in various disease states.
  • To provide a comprehensive overview of adaptive immunity's role in immunothrombosis.

Main Methods:

  • Literature review of studies investigating adaptive immunity and thrombosis.
  • Analysis of mechanisms by which adaptive immune cells modulate coagulation.
  • Synthesis of data from autoimmune, allergic, infectious, and ischemic conditions.

Main Results:

  • Adaptive immune cells actively participate in the processes of clot formation and resolution.
  • The adaptive immune system significantly modulates procoagulant activity in diverse pathological conditions.
  • Specific examples include inflammatory bowel disease, systemic lupus erythematosus, dermatitis, asthma, COVID-19, HIV, myocardial infarction, and stroke.

Conclusions:

  • Adaptive immune cells are integral components of immunothrombosis.
  • Understanding this role is critical for elucidating thrombosis risk in various immune-mediated and infectious diseases.
  • Targeting adaptive immune pathways may offer novel therapeutic strategies for thrombotic disorders.