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Unraveling PANoptosis a key player in acute kidney injury and its clinical implications

Songyuan Yang1, Zehua Ye1, Sheng Zhao1

  • 1Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Translational Research : the Journal of Laboratory and Clinical Medicine
|November 13, 2025
PubMed

Insights

Acute kidney injury (AKI) is a major health issue. Targeting PANoptosis, a novel cell death pathway, shows promise for developing new AKI treatments by intervening in the PANoptosome complex.

Area of Science:

  • Nephrology
  • Cell Biology
  • Immunology

Background:

  • Acute kidney injury (AKI) presents a significant global health challenge with high morbidity and mortality rates.
  • PANoptosis is an emerging cell death pathway involving pyroptosis, apoptosis, and necroptosis.
  • The PANoptosome complex integrates multiple cell death pathways, highlighting its complex role.

Purpose of the Study:

  • To review recent advancements in understanding PANoptosis in the context of AKI.
  • To explore the therapeutic potential of targeting PANoptosis for AKI treatment.
  • To identify and discuss potential therapeutic targets within the PANoptosis pathway for AKI.

Main Methods:

  • Literature review of recent research on PANoptosis and AKI.
  • Analysis of the molecular mechanisms of PANoptosis.
  • Examination of studies investigating therapeutic interventions targeting cell death pathways in AKI.

Main Results:

  • PANoptosis plays a critical role in the pathogenesis of AKI.
  • The PANoptosome complex is a key mediator of cell death in AKI.
  • Targeting PANoptosis presents a promising therapeutic strategy for AKI.

Conclusions:

  • Understanding PANoptosis is crucial for advancing AKI treatment strategies.
  • Interventions targeting the PANoptosome complex could offer novel therapeutic avenues for AKI.
  • Further research into PANoptosis mechanisms may lead to more effective AKI therapies.
Keywords:
Acute kidney injuryApoptosisNecroptosisPANoptosisProgrammed cell deathPyroptosisTherapeutic targets

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