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Long-term safety and tolerability of frespaciguat: INSIGNIA-PAH extension

Marc Humbert1, Paul M Hassoun2, Kelly M Chin3

  • 1Université Paris-Saclay, Faculté de Médecine, Inserm UMR_S 999, Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital Bicêtre (Assistance Publique - Hôpitaux de Paris), Le Kremlin-Bicêtre, France marc.humbert@aphp.fr.

The European Respiratory Journal
|November 13, 2025
PubMed
Abstract

No abstract available in PubMed .

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Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
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