Related Experiment Video
Updated: Jan 11, 2026
09:37
Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
2.8K
[Cutaneous squamous cell carcinoma]
1Service de dermatologie, hôpital Cochin-AP-HP. Centre-Université Paris Cité, 123, boulevard de Port-Royal, 75014 Paris, France.
Annales De Chirurgie Plastique Et Esthetique
|November 13, 2025
Summary
Cutaneous squamous cell carcinoma (CSC) is a common skin cancer with increasing incidence. Early surgery offers cures, while advanced cases benefit from immunotherapy over chemotherapy due to better efficacy and tolerability.
Area of Science:
- Dermatology
- Oncology
Background:
- Cutaneous squamous cell carcinoma (CSC) is the second most common skin cancer, representing 20% of all diagnoses.
- Its incidence has significantly increased in recent decades.
- CSC is a malignant epithelial tumor originating from keratinocytes.
Purpose of the Study:
- To summarize the characteristics, management, and treatment advancements for cutaneous squamous cell carcinoma.
- To highlight the shift towards immunotherapy in advanced CSC cases.
Main Methods:
- Review of current literature on CSC epidemiology, pathology, and treatment modalities.
- Analysis of treatment outcomes comparing surgery, radiotherapy, chemotherapy, and immunotherapy.
Main Results:
- CSC exhibits more rapid progression than basal cell carcinoma, with risks of recurrence and metastasis.
- Early surgical intervention typically results in a cure.
- Adjuvant radiotherapy is recommended for poor-prognosis cases.
- Immunotherapy demonstrates superior efficacy (40-50% response rate) and tolerability compared to chemotherapy for advanced CSC.
Conclusions:
- Effective management of CSC involves early surgical treatment, with adjuvant radiotherapy for high-risk patients.
- Immunotherapy represents a significant advancement in treating advanced cutaneous squamous cell carcinoma, offering improved outcomes and patient tolerance.
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