Related Experiment Video
Updated: Jan 11, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
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[Melanoma: Systemic treatments (part 2)]
1Service de dermatologie, hôpital Cochin, AP-HP Centre, université Paris Cité, 123, boulevard de Port-Royal, 75014 Paris, France.
Annales De Chirurgie Plastique Et Esthetique
|November 13, 2025
Summary
Immune checkpoint inhibitors and targeted therapies have revolutionized melanoma treatment since the 2010s. These advancements now offer new options for high-risk melanoma patients as neoadjuvant and adjuvant therapies.
Area of Science:
- Oncology
- Immunology
- Dermatology
Background:
- Melanoma management has significantly evolved since the 2010s.
- Immune checkpoint inhibitors and targeted therapies are key advancements.
Purpose of the Study:
- To review the transformative impact of novel therapies on melanoma treatment.
- To highlight the application of these therapies in neoadjuvant and adjuvant settings for high-risk melanoma.
Main Methods:
- Literature review of studies published since the 2010s.
- Analysis of clinical trial data and treatment guidelines.
- Focus on immune checkpoint inhibitors and anti-BRAF/anti-MEK therapies.
Main Results:
- These therapies have dramatically improved outcomes for advanced and metastatic melanoma.
- Neoadjuvant and adjuvant use is established for high-risk melanoma (Stage IIB-IIID).
- Significant survival benefits observed in treated patient populations.
Conclusions:
- Immune checkpoint inhibitors and targeted therapies represent a paradigm shift in melanoma care.
- Their neoadjuvant and adjuvant application offers new hope for high-risk melanoma patients.
- Continued research is essential to optimize treatment strategies and patient selection.
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