Related Experiment Video
Updated: Jan 11, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
Life stage transitions for people with type 1 diabetes
Rebecca J Vitale1, Elena Toschi2, Jacob Ortega3
1Division of Pediatric Endocrinology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Endocrinology and Metabolism, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Type 1 diabetes care needs change across life stages. This study identifies common challenges during emerging adult and older adult transitions to improve lifelong diabetes management.
Area of Science:
- Endocrinology
- Lifespan Studies
- Diabetes Management
Background:
- Type 1 diabetes (T1D) management requires evolving strategies throughout an individual's life.
- Key life transitions, such as emerging adulthood and older adulthood, present unique challenges in T1D care.
- Understanding these transitions is crucial for providing continuous, age-appropriate support.
Purpose of the Study:
- To define and analyze the major life stage transitions in type 1 diabetes management.
- To identify common domains and challenges across the emerging adult and older adult transitions.
- To propose a framework for improving T1D care across the lifespan.
Main Methods:
- Literature review and conceptual framework development.
- Analysis of clinical priorities and support needs at different life stages.
- Identification of eight common domains relevant to both transitions.
Main Results:
- Two major transitions identified: emerging adult (18-25 years) and older adult (variable age).
- Eight common domains identified: medical team needs, self-management education, physiological adaptation, comorbidities, neurocognition, functional status, independence, and financial context.
- Similarities in transition challenges can inform care improvements.
Conclusions:
- A unified framework addressing common domains can enhance T1D care during critical life transitions.
- Further research is needed to address clinical gaps and optimize support for individuals with T1D across all ages.
- Leveraging similarities between transitions can lead to more effective, lifelong diabetes management strategies.
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes: Symptoms, Diagnosis, and Complications
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...

