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A STIMulating new view of activity-dependent membrane contact architecture

Eamonn J Dickson1

  • 1Department of Physiology and Membrane Biology, University of California, Davis, CA 95616, USA.

Trends in Cell Biology
|November 13, 2025
PubMed
Summary

Stromal interaction molecule (STIM) proteins organize neuronal membrane contact sites. STIM2 stabilizes resting junctions, while STIM1 expands them during activity, regulating calcium signaling through spatial organization.

Keywords:
ER–PM junctionsNMDAR-dependent remodelingSTIM1/STIM2calciumdendritic microdomainsstore-operated Ca(2+) entry (SOCE)

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