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Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

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Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...

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Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

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Differentiable simulation expands frontiers for biophysical neural models

Samuel A Neymotin^1,2, Hananel Hazan^3,4

¹Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA. Samuel.Neymotin@NKI.RFMH.ORG.

|November 13, 2025

Summary

No abstract available in PubMed .

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