SrO-Containing Bioactive Glasses in the SiO₂-CaO-P₂O₅ System: A Comprehensive Review

Area of Science:

• Materials Science
• Biomaterials Engineering
• Biomedical Research

Background:

• Bioactive glasses (BGs) are crucial biomaterials for bone regeneration.
• The SiO₂-CaO-P₂O₅ system is a common BG base.
• Strontium oxide (SrO) incorporation is a recent modification for enhanced properties.

Purpose of the Study:

• To review recent advances in SiO₂-CaO-P₂O₅-SrO bioactive glasses.
• To highlight the impact of SrO on structural, thermal, and biological characteristics.
• To provide insights for optimizing Sr-doped BGs in bone tissue engineering.

Main Methods:

• Comprehensive literature review of studies on SrO-modified BGs.
• Analysis of structural, thermal, and mechanical property changes.
• Evaluation of in vitro and in vivo biological performance data.

Main Results:

• SrO incorporation influences glass network connectivity, mechanical strength, and thermal stability.
• SrO affects dissolution, bioactive phase formation, cellular response, and antimicrobial activity.
• SrO concentration and substitution levels are critical for bone regeneration and biocompatibility.

Conclusions:

• Sr-doped BGs show significant potential for enhanced bone tissue engineering applications.
• Optimization of SrO content is key to maximizing benefits.
• Further in vivo and clinical studies are warranted to translate findings into practice.