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Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Related Experiment Video

Updated: Jan 11, 2026

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
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[Wip1 Phosphatase Regulates Hematopoietic Function in Mouse Spleen].

Xiao-Ping Ren1, Zhi-Lin Chang2, Yi Wang2

  • 1Forensic Medicine College of Shanxi Medical University, Taiyuan 030606, Shanxi Province, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|November 14, 2025
PubMed
Summary

Wip1 phosphatase deletion impairs mouse spleen hematopoietic function, reducing mature cell numbers and promoting inflammation in myeloid cells. This highlights Wip1

Area of Science:

  • Hematopoiesis research
  • Immunology
  • Molecular biology
Keywords:
Wip1 phosphatase; spleen; hematopoiesis; inflammatory cytokines

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