Related Experiment Video
Updated: Jan 11, 2026

CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications
Published on: August 9, 2022
[Research Progress of Epigenetic Modification in Hematopoietic Stem Cell Functional Regulation--Review]
Chun-Yuan Liang1, Rui-Ting Wen1, Zhi-Gang Yang1
1Department of Hematology, Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang 524045, Guangdong Province, China.
None:
In recent years, with the development of single-cell sequencing technology, spatial transcriptome technology and in vivo tracing technology, scientists have a deeper understanding of scientific issues about the in vivo development, functional regulation and ex vivo expansion of hematopoietic stem cells (HSCs). Among them, epigenetic modification plays an important role in the development and fate decisions, function maintenance and ex vivo expansion of HSCs, which has become a research hotspot in the field of stem cells in recent years. This article reviews the recent research progress of epigenetic modification in the development, functional regulation and expansion of HSCs.
Related Concept Videos
Regulation of Hematopoietic Stem Cells
Lineage Commitment
Multipotency of Hematopoietic Stem Cells
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
Hematopoiesis
Epigenetic Regulation
X-chromosome...

