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Updated: Jan 11, 2026

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Published on: March 11, 2017
Association between thyroid function and metabolic associated fatty liver disease: a systemic review and
Wei Xiong1, Hua Fan2, Jiake Tang3
1The First People's Hospital of Jiande, Hangzhou, China.
Thyroid dysfunction, particularly elevated thyroid-stimulating hormone (TSH), is linked to metabolic dysfunction-associated fatty liver disease (MAFLD). Age influences this relationship, highlighting TSH as a potential risk factor for MAFLD development.
Area of Science:
- Endocrinology
- Hepatology
- Metabolic Diseases
Background:
- Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent chronic liver condition.
- The association between MAFLD and thyroid function remains a subject of ongoing research and debate.
Purpose of the Study:
- To investigate the impact of metabolic factors and thyroid dysfunction on MAFLD development.
- To analyze the relationship between MAFLD and thyroid parameters across different age demographics.
Main Methods:
- A systematic literature search was conducted across major databases (PubMed, Embase, Web of Science, CNKI, Cochrane Library).
- Meta-analysis was performed using standardized mean difference (SMD) and odds ratio with 95% confidence intervals (CI).
Main Results:
- Analysis of 36 studies with 198,254 participants revealed significant differences in thyroid function in MAFLD patients compared to controls.
- Elevated thyroid-stimulating hormone (TSH), free triiodothyronine, and total triiodothyronine were observed in MAFLD patients.
- Reduced levels of free thyroxine and total thyroxine were noted in individuals with MAFLD.
Conclusions:
- Thyroid-stimulating hormone (TSH) may represent a significant risk factor in the pathogenesis of MAFLD.
- The interplay between thyroid function and MAFLD is modulated by patient age.
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