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Preparation of Binary and Ternary Deep Eutectic Systems
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Assessing Sodium Amide Reagents for Ester Amidations in Deep Eutectic Solvents in Continuous Flow

Andrew W J Platten1, Bruno Pinho2, Laura Torrente-Murciano2

  • 1Department für Chemie Biochemie und Pharmazie, Universität Bern, Freiestrasse 3, 3012 Bern, Switzerland.

ACS Sustainable Chemistry & Engineering
|November 14, 2025
PubMed
Summary

This study introduces sodium amides in deep eutectic solvents (DES) for efficient ester and C-F bond amidation under mild conditions. This novel approach in continuous flow chemistry enhances reactivity and prevents reactor clogging by dispersing byproducts.

Keywords:
Deep Eutectic Solventscontinuous flowsodium amidessolvent effectssustainable organometallic reagents

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