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Updated: Jan 11, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Sex Differences in the Association of Obesity With Prediabetes and Dyslipidemia Among Adolescents: A Cross-Sectional
Ali H Ziyab1, Aishah Saadallah1, Zainab Almousa1
1Department of Community Medicine and Behavioral Sciences College of Medicine Kuwait University Safat Kuwait.
Background:
Limited knowledge exists on whether obesity during early life stages demonstrates sex-specific associations with cardiometabolic conditions. Therefore, this study aimed to determine if the association of obesity with prediabetes and dyslipidemia differs according to sex among adolescents.
Methods:
Adolescents aged 14-19 years were enrolled in a cross-sectional study. Capillary blood was used to measure glycated hemoglobin and lipids. Prediabetes and dyslipidemia were determined according to international guidelines. Associations and statistical interactions (body mass index-for-age × sex) were evaluated using multivariable logistic regression models.
Results:
Data from a total of 1584 adolescents (826 female participants) were analyzed in the current report. Obesity (38.6% vs. 24.4%) and dyslipidemia (54.2% vs. 36.7%) were more prevalent in male than female participants; however, prediabetes prevalence did not differ between male and female participants (34.8% vs. 33.8%). The association between obesity and prediabetes differed according to sex (P interaction = 0.046), with obesity showing a stronger association among female participants (adjusted odds ratios [aOR]: 3.24; 95% confidence interval [CI]: 2.25, 4.66) compared with male participants (aOR: 1.64; 95% CI: 1.12, 2.39). However, obesity showed a stronger association with dyslipidemia among male participants (aOR: 2.74; 95% CI: 1.93, 3.90) compared with female participants (aOR: 1.49; 95% CI: 1.04, 2.13; P interaction = 0.016).
Conclusion:
Obesity demonstrated sex-specific associations with cardiometabolic conditions in adolescents, showing a stronger association with prediabetes in females but with dyslipidemia in males.
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