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Diffuse midline glioma, H3K27-altered, mimicking central neurocytoma on MRI: A case report
Yasuyuki Kojita1, Tomonori Kanda1, Shiho Yokoo1
1Department of Radiology, Kobe Graduate University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan.
Abstract:
Diffuse midline glioma (DMG), H3K27-altered, is an aggressive central nervous system tumor that usually arises in midline structures such as the pons, thalamus, or spinal cord. We present a rare case of intraventricular DMG, H3K27-altered in a 35-year-old woman. MRI showed a soap-bubble appearance, initially suggestive of central neurocytoma, but histopathological and immunohistochemical analyses confirmed the final diagnosis of DMG, H3K27-altered. This is the first reported intraventricular DMG, H3K27-altered with a soap-bubble appearance, underscoring the importance of including this tumor in the differential diagnosis of intraventricular masses.
Insights
This study reports a rare intraventricular diffuse midline glioma (DMG), H3K27-altered, in a woman. The tumor presented a unique soap-bubble appearance on MRI, highlighting diagnostic considerations for intraventricular masses.
Area of Science:
- Neuro-oncology
- Central Nervous System (CNS) Pathology
- Medical Imaging
Background:
- Diffuse midline glioma (DMG), H3K27-altered, is a highly aggressive CNS tumor typically found in midline structures.
- Intraventricular locations for this tumor type are exceptionally rare.
- Accurate diagnosis is crucial due to the tumor's aggressive nature.
