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Advancements in Fibrinogen Replacement for Major Bleeding: Insights From Case Series

David S Shapiro1, Daniel Katz2, John J Kowalczyk3

  • 1Department of Surgery, University of Connecticut School of Medicine, Farmington, USA.

Cureus
|November 14, 2025
PubMed
Summary

Timely fibrinogen replacement is crucial for managing major bleeding in cardiac, obstetric, and trauma patients. Using fibrinogen concentrate or pathogen-reduced cryoprecipitate can rapidly restore clot stability and improve outcomes.

Keywords:
anesthesiologybleedingbleeding and blood productscardiac surgeryfibrinogenobstetrical hemorrhageresuscitationtraumatic hemorrhage

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