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Self-Assembly of Microtubule Tactoids

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Published on: June 23, 2022

A self-assembled macrocycle with a non-closed structure for hierarchically upgraded self-assembly.

Ze Cao¹, Chenqi Ge¹, Guangcheng Wu²

¹Departmsent of Chemistry, Zhejiang University Hangzhou 310058 China.

Chemical Science

|November 14, 2025

Summary

Researchers created a novel macrocycle that, after selective removal of amino groups, forms a dialdehyde intermediate. This intermediate enables hierarchical self-assembly into complex structures with diverse amine building blocks.

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Area of Science:

Supramolecular Chemistry
Organic Synthesis

Background:

Macrocycles are large ring structures with diverse applications.
Hierarchical self-assembly is a key strategy for constructing complex molecular architectures.
Controlling the assembly of molecules with multiple functional groups remains a challenge.

Purpose of the Study:

To report the serendipitous self-assembly of a novel [3 + 10] non-closed macrocycle.
To demonstrate a method for generating a dialdehyde intermediate from the macrocycle.
To showcase the utility of this intermediate in hierarchical self-assembly for creating complex structures.

Main Methods:

Self-assembly of a [3 + 10] non-closed macrocycle.
Selective removal of unreacted amino groups via imine exchange.
Utilizing the resulting dialdehyde intermediate for further self-assembly.

Main Results:

Successful serendipitous formation of a [3 + 10] non-closed macrocycle.
Selective deprotection yielding a reactive dialdehyde intermediate.
Hierarchical self-assembly into structures with two distinct amine building blocks.

Conclusions:

The developed macrocycle and subsequent deprotection strategy provide a novel route to complex molecular architectures.
This method allows for the construction of structures with specific amine building blocks, not achievable through one-pot synthesis.
Opens new avenues for designing and synthesizing advanced supramolecular materials.