Related Experiment Video

Updated: Jan 11, 2026

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

25.0K

The drug discovery and therapeutic nano-strategies targeting cellular senescence

Yumei Wang1, Mingqi Liu2, Xinzhao Chen3

  • 1Department of Pharmaceutics, College of Pharmacy, Army Medical University, Chongqing, 400038, China.

Materials Today. Bio
|November 14, 2025
PubMed

Insights

Cellular senescence, driven by accumulating senescent cells (SnCs), drives aging and related diseases. Nanotechnology offers novel drug delivery systems (NDDS) to target SnCs for effective anti-aging therapies.

Area of Science:

  • Gerontology and Nanomedicine: Interdisciplinary approach to aging and disease treatment.

Background:

  • Cellular senescence, characterized by accumulating senescent cells (SnCs), is a key driver of aging and associated pathologies.
  • Current anti-aging strategies include senolytic and senomorphic drugs, NAD+ enhancers, and immunomodulatory therapies.

Purpose of the Study:

  • To review molecular mechanisms of cellular senescence.
  • To analyze therapeutic strategies, focusing on nanotechnology-based drug delivery systems (NDDS) for targeting SnCs.
  • To explore applications in aging-related diseases like neurodegenerative, cardiovascular, and fibrotic conditions.

Main Methods:

  • Comprehensive literature review of cellular senescence mechanisms and therapeutic interventions.
  • Analysis of NDDS design principles, formulation, and targeted delivery strategies for SnCs.
  • Examination of nano-strategies for treating specific aging-related diseases.

Main Results:

  • Senolytic and senomorphic drugs, NAD+ enhancers, and immunotherapies show promise in targeting senescence.
  • Engineered NDDS offer advanced approaches for drug loading, targeted delivery, and stimuli-responsive release to SnCs.
  • Nano-strategies demonstrate potential across diverse aging-related diseases, including neurodegeneration and cancer.

Conclusions:

  • Targeting cellular senescence with NDDS presents significant therapeutic potential for aging-related diseases.
  • Further research and SWOT analysis are crucial for optimizing nano-strategies and advancing precision medicine in aging.
  • Developing innovative and effective approaches for aging-related disease management is the ultimate goal.
Keywords:
Aging-related diseaseNanotechnology-based drug delivery systemSWOT analysisSenescent cellsSenotherapy

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