The Relation between Exercise and Non-Motor Symptoms in Parkinson's Disease

Area of Science:

• Neurology
• Exercise Science
• Psychiatry

Background:

• Most Parkinson's disease (PwPD) exercise programs prioritize motor function over non-motor symptoms (NMS).
• NMS significantly impact the quality of life for individuals with Parkinson's disease.

Purpose of the Study:

• To investigate the relationship between self-reported exercise and various NMS in PwPD.
• To explore how exercise dosage (frequency and duration) correlates with NMS severity.

Main Methods:

• An online survey assessed exercise engagement and NMS in 347 individuals with Parkinson's disease.
• Demographically matched groups of exercisers and non-exercisers were compared.
• Associations between exercise dosage and NMS were analyzed using logistic regression.

Main Results:

• Individuals with Parkinson's disease who exercised reported fewer and less severe NMS compared to non-exercisers.
• Higher exercise frequency was associated with lower fatigue and better subjective cognition.
• Moderate and high exercise frequencies correlated with reduced depression, anxiety, fatigue, and improved cognition.

Conclusions:

• Exercise engagement is associated with improved NMS in PwPD.
• Addressing NMS, especially fatigue, may enhance exercise participation in PwPD.
• Healthcare providers should consider discussing exercise benefits for NMS with patients.