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Multifunctional nanomaterials for dental photo-theranostics
Yujia Shi1, Xiaolin Sun1, Jiao Fang1
1Department of Oral Implantology, Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering, School and Hospital of Stomatology, Jilin University, Changchun 130021, China.
Chemical Society Reviews
|November 14, 2025
Summary
Photo-responsive nanomaterials offer targeted, non-invasive treatments for dental diseases. These light-activated nanotechnologies enable precise, site-specific interventions with minimal side effects, revolutionizing dental care.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Photomedicine
Background:
- Dental diseases require innovative diagnostic and therapeutic solutions.
- Nanomaterials offer advanced capabilities for targeted interventions.
- Photo-responsive technologies provide non-invasive, controllable treatment modalities.
Purpose of the Study:
- To review light-responsive nanomaterials for dental applications.
- To explore mechanisms, performance, and translational potential.
- To identify challenges and recommend future strategies for photo-theranostic platforms.
Main Methods:
- Comprehensive literature review of photo-responsive nanomaterials in dentistry.
- Analysis of mechanisms of action under light stimulation.
- Evaluation of performance against conventional treatments and assessment of translational potential.
Main Results:
- Diverse light-activated nanomaterials (inorganic, organic, hybrid) show promise for dental diagnostics and therapeutics.
- Photo-responsive strategies enable precise, spatiotemporal control of interventions.
- Challenges include biocompatibility, light penetration depth, and complex oral environments.
Conclusions:
- Light-responsive nanomedicine holds significant potential for advanced dental disease management.
- Further research is needed to overcome clinical implementation challenges.
- Next-generation photo-theranostic platforms require integrated design principles for effective translation.
