From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)
Jingwen Wu1, Xuxia Cai1, Zimo Zhu1
1Department of Dermatology, Skin Research Institute of Peking University Shenzhen Hospital, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
Abstract:
Melanoma, a highly malignant form of skin cancer, poses significant challenges in oncology due to its aggressive nature and resistance to conventional therapies. Epigenetic modifications, especially acetylation, have emerged as critical regulators of gene expression that influence the pathogenesis and progression of melanoma. Acetylation is a novel post‑translational modification that involves the addition of an acetyl group to lysine residues both in histone and in non‑histone proteins. In the context of melanoma, acetylation has been shown to occupy a pivotal role in regulating cellular proliferation, autophagy, apoptosis and metastasis, as well as drug resistance. The identification of acetylation‑associated biomarkers and therapeutic targets in melanoma is currently an active area of research. The present review aims to elucidate the roles of acetylation modifications in melanoma, and to explore the potential of targeting these modifications for novel therapeutic interventions, with a unique perspective on the acetylation networks mediating therapy resistance.
Insights
Acetylation, a key epigenetic regulator, plays a crucial role in melanoma development and drug resistance. Targeting acetylation pathways offers promising new therapeutic strategies for this aggressive skin cancer.
Area of Science:
- Oncology
- Epigenetics
- Molecular Biology
Background:
- Melanoma is an aggressive skin cancer known for treatment resistance.
- Epigenetic modifications, particularly acetylation, are increasingly recognized as key drivers of melanoma.
- Acetylation influences critical cellular processes like proliferation, autophagy, apoptosis, and metastasis.
Purpose of the Study:
- To review the multifaceted roles of acetylation in melanoma pathogenesis and progression.
- To explore acetylation as a potential therapeutic target for melanoma.
- To examine acetylation networks involved in mediating resistance to cancer therapies.
Main Methods:
- Literature review of studies on acetylation in melanoma.
- Analysis of epigenetic mechanisms in melanoma.
- Investigation of acetylation-associated biomarkers and therapeutic targets.
Main Results:
- Acetylation significantly impacts melanoma cell proliferation, survival, and spread.
- Acetylation patterns are linked to resistance against conventional melanoma treatments.
- Specific acetylation modifications are potential biomarkers and targets for novel therapies.
Conclusions:
- Acetylation is a critical regulatory mechanism in melanoma.
- Targeting acetylation pathways presents a promising avenue for developing new melanoma treatments.
- Understanding acetylation networks is vital for overcoming therapy resistance in melanoma.
Related Concept Videos
02:25Spreading of Chromatin Modifications
Writers
The writer is an enzyme that can...
02:23Abnormal Proliferation
02:53Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:57Targeted Cancer Therapies
There are several types of targeted therapies against specific...
02:53Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...