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![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Palladium-Catalyzed Chemoselective Direct Arylation of Polyfluoroarenes With Chloroaryl Triflates at the C-Cl Bond
Zifang Peng1, Changxue Gu1, On Ying Yuen1
1Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
Abstract:
This study describes a palladium-catalyzed chemoselective direct arylation of polyfluoroarenes with chloro(hetero)aryl triflates, achieving site-selective functionalization at the C-Cl bond for the first time. The recently developed alkyl-pyrazole-based phosphine ligand (BirdPhos) proved essential for the success of this transformation, affording excellent yields with high chemoselectivity. Moreover, the catalytic system enables the efficient synthesis of a broad range of functionalized polyfluoroarene derivatives under mild, additive-free conditions. Notably, the reaction retains the triflate group in the products, providing a versatile functional handle for further derivatization and highlighting the broad applicability and synthetic utility of this method.
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