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Cell-free transcriptomic profiles and mechanism insights in female androgenetic alopecia

Lingling Jia1, Mingyang Lu1,2, Siwei Deng3,4

  • 1Department of Plastic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Clinical and Translational Medicine
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PubMed
Abstract

No abstract available in PubMed .

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

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