Comparison of Sedation Efficacy Between Propofol-ketamine and Propofol-fentanyl Combinations in Short Gynecological...

This study aimed to compare the sedoanalgesic efficacy and side effects between propofol-ketamine and propofol-fentanyl combinations in short gynecological procedures for increasing surgical analgesia and improving patient comfort.

This was a randomized (1:1), double-blind, prospective trial.

This randomized, double-blind controlled trial included patients who underwent short gynecological procedures lasting less than 30 minutes. Group K (n = 30) received 0.5 mg/kg ketamine and 1 mg/kg propofol, whereas group F (n = 30) received 1 mcg/kg fentanyl and 1 mg/kg propofol. The sedation levels, hemodynamic changes, adverse events, and both surgical and patient satisfaction were evaluated.

Lower extremity movement was more frequently observed in group F (P = .020), but surgical satisfaction was higher in group K (P < .001). Both groups exhibited similar sedation, surgical time, and patient satisfaction scores. However, group F had shorter recovery times and exhibited more frequent apnea and desaturation. Furthermore, postoperative dizziness was more common in this group (P = .003).

Both drug combinations provide safe anesthesia with stable hemodynamics and fewer side effects. The use of propofol-ketamine resulted in fewer lower extremity movements, leading to greater surgical satisfaction.