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Related Experiment Video

Updated: Jan 11, 2026

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation

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Published on: May 2, 2020

[Dietary supplements for dry eye disease].

Barbara Sophie Brunner¹, S Kassumeh², S G Priglinger²

¹Augenklinik und Poliklinik, LMU Klinikum, LMU München, Mathildenstr. 8, 80336, München, Deutschland. barbara.brunner@med.uni-muenchen.de.

Die Ophthalmologie

|November 14, 2025

Summary

Nutritional supplements, including omega fatty acids, show promise for managing dry eye disease by reducing inflammation and oxidative stress. Further research is needed to optimize dosages and combination therapies.

Keywords:

Minerals Omega‑3 fatty acids Probiotics Trace elements Vitamins

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Establishment of A Mouse Model of Aqueous Deficiency Dry Eye

Establishment of A Mouse Model of Aqueous Deficiency Dry Eye

Published on: November 1, 2024

Area of Science:

Ophthalmology
Nutrition Science
Biochemistry

Background:

Dry eye disease is a common ocular surface condition linked to inflammation and oxidative stress.
Inflammatory processes and reactive oxygen species (ROS) damage corneal and goblet cells, destabilizing the tear film.
This damage exacerbates ocular surface issues in dry eye disease.

Purpose of the Study:

To review dietary supplements with demonstrated positive effects on the ocular surface in dry eye disease.
To summarize findings from clinical studies on nutritional interventions for dry eye.

Main Methods:

A systematic review of English-language studies up to July 2025 was conducted.
PubMed was used as the primary database, with keywords including essential fatty acids, vitamins, and probiotics.
Studies were analyzed for quantitative and qualitative data on the impact of dietary supplements.

Main Results:

Essential fatty acids, vitamins, trace elements, minerals, phytochemicals, and probiotics are key nutrient categories for dry eye.
Oral supplementation demonstrated positive outcomes, with omega fatty acids being the most studied (Level 1 evidence).
Regular blood count monitoring is advised for long-term oral supplementation.

Conclusions:

Nutritional supplementation offers a promising avenue for dry eye disease management.
Further clinical research is essential to determine optimal dosages and synergistic effects with conventional treatments.