Lacticaseibacillus Paracasei CCFM1350 Demonstrates Potentials in Hair Growth and Treating Alopecia in Mice

Area of Science:

• Microbiology
• Dermatology
• Gastroenterology

Background:

• Alopecia significantly impacts quality of life, necessitating treatments that target underlying biological pathways.
• Current treatments often address superficial damage, highlighting the need for novel therapeutic strategies.
• Modulating key signaling pathways is crucial for effective alopecia management.

Purpose of the Study:

• To investigate the efficacy of Lacticaseibacillus paracasei CCFM1350 live bacteria in promoting hair growth.
• To elucidate the molecular mechanisms underlying CCFM1350's effects on hair regeneration.
• To explore the potential of CCFM1350 as a probiotic treatment for alopecia.

Main Methods:

• Animal experiments were conducted to assess hair growth following CCFM1350 administration.
• Biochemical assays were employed to analyze the Wnt/β-catenin signaling pathway.
• Gut microbiota composition was analyzed using sequencing techniques.

Main Results:

• CCFM1350 live bacteria administration resulted in a 3.464-fold increase in hair growth compared to controls.
• Wnt10b and β-catenin expression levels were significantly upregulated (243% and 35.56%, respectively).
• Significant alterations in gut microbiota, including increased Verrucomicrobia and Bacteroidetes, were observed.

Conclusions:

• L. paracasei CCFM1350 demonstrates significant potential as a probiotic for promoting hair growth.
• The Wnt/β-catenin signaling pathway is a key mediator of CCFM1350's hair growth-promoting effects.
• CCFM1350 offers a natural alternative to conventional alopecia treatments like Finasteride.