Lacticaseibacillus Paracasei CCFM1350 Demonstrates Potentials in Hair Growth and Treating Alopecia in Mice

Alopecia, a prevalent condition characterized by patterned or complete hair loss, significantly impacts quality of life. Effective treatments require modulation of underlying biological pathways rather than addressing superficial damage to skin or hair follicles. This study investigates Lacticaseibacillus paracasei CCFM1350 live bacteria as a potential intervention for promoting hair growth and treating alopecia. Through a series of animal experiments and biochemical assays, we demonstrate that CCFM1350 live bacteria significantly enhance hair growth via the Wnt/β-catenin signaling pathway. Specifically, the administration of CCFM1350 resulted in a 3.464-fold increase in hair growth compared to the control group. This effect was associated with a 243% increase in Wnt10b expression and a 35.56% increase in β-catenin expression. Additionally, significant alterations in the gut microbiota were observed in the CCFM1350-treated group, including changes in the abundance of Verrucomicrobia and Bacteroidetes at the phylum level and Akkermansia at the genus level. These findings suggest that L. paracasei CCFM1350 could serve as a viable probiotic treatment for alopecia, providing a natural alternative to conventional drugs like Finasteride.