Related Experiment Video

Updated: Jan 11, 2026

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
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Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

Published on: July 29, 2014

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Primer investigation of RIG-I-like receptors expression in virus infection with the acute character

Filip Lewandowski1,2, Rafał Hrynkiewicz1,2, Karolina Wiśniewska1,3

  • 1Centre for Experimental Immunology and Immunobiology of Infectious and Cancer Diseases, University of Szczecin, Szczecin, Poland.

Innate Immunity
|November 14, 2025
PubMed

Insights

Rabbit Hemorrhagic Disease virus infection increases RIG-I-like receptor (RLR) expression, particularly RIG-I, in European rabbits. This suggests RLRs play a key role in the host immune response to Lagovirus europaeus.

Area of Science:

  • Virology
  • Immunology
  • Pathogenesis

Background:

  • Rabbit Hemorrhagic Disease (RHD) is caused by Lagovirus europaeus/GI.2.
  • The acute pathogenesis of RHD remains poorly understood.
  • Lack of in vitro models hinders RHD vaccine development.

Purpose of the Study:

  • To investigate the expression of RIG-I-like receptors (RLRs) during Lagovirus europaeus infection.
  • To elucidate the role of RLRs in the host immune response to RHD.

Main Methods:

  • European rabbits were infected with Lagovirus europaeus/GI.2.
  • Expression levels of RLRs (RIG-I, MDA5, LGP2) were analyzed.

Main Results:

  • A significant increase in RLR expression was observed during infection.
  • Elevated RLR expression was prominent in organs showing severe pathology.
  • RIG-I showed a particularly notable increase in expression.

Conclusions:

  • RLRs, especially RIG-I, are likely crucial in the host defense against Lagovirus europaeus.
  • Findings provide insights into RHD pathogenesis and potential therapeutic targets.
Keywords:
Lagovirus europeausRHDV2RLRRabbit Hemorrhage Diseasegene expression

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