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Updated: Jan 11, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

517

Blood pressure variability is associated with heart failure risk, elevated NT-proBNP, and elevated high-sensitivity

Daniel S Nuyujukian1,2, Jin J Zhou1,3, Juraj Koska2

  • 1Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, United States.

American Journal of Hypertension
|November 14, 2025
PubMed

Insights

Blood pressure variability (BPV) is linked to increased risk of heart failure (HF) and early signs of heart damage. These findings suggest BPV may play a role in HF development.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Epidemiology

Background:

  • The relationship between blood pressure variability (BPV) and incident heart failure (HF) remains unclear.
  • Subclinical markers of HF and myocardial injury also need further investigation regarding their association with BPV.

Purpose of the Study:

  • To investigate the association between visit-to-visit BPV and the risk of incident HF.
  • To examine the link between BPV and subclinical markers of HF and myocardial injury.

Main Methods:

  • The Multi-Ethnic Study of Atherosclerosis (MESA) cohort (n=6,814) was used, with individuals free of cardiovascular disease at baseline.
  • Visit-to-visit BPV was estimated using variability independent of the mean (VIM) from serial blood pressure measurements.
  • Cox models and joint longitudinal-survival models assessed the association with HF, while logistic regression analyzed associations with N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin-T (hs-cTnT).

Main Results:

  • BPV, specifically VIM-SBP, was significantly associated with an increased risk of incident HF (HR=1.33).
  • BPV was associated with elevated NT-proBNP levels (VIM-SBP OR=1.26; VIM-DBP OR=1.23).
  • BPV (VIM-SBP) was also linked to elevated hs-cTnT levels (OR=1.27), indicating myocardial injury.

Conclusions:

  • Visit-to-visit blood pressure variability is associated with incident heart failure.
  • BPV is linked to longitudinal increases in subclinical markers of HF and myocardial injury.
  • These findings suggest that BPV may contribute to the development of heart failure.
Abstract

Keywords:
blood pressureepidemiologyheart failurehypertensionsubclinical markervariability

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