Modulating Systemic Immune-Inflammatory Indices via Double Filtration Plasmapheresis: Implications for Aging and...

Area of Science:

• Clinical Medicine
• Immunology
• Hematology

Background:

• Systemic immune-inflammatory indices from complete blood counts indicate inflammation.
• Double filtration plasmapheresis lowers lipids and removes inflammatory mediators, but its impact on these indices is not well-documented.

Purpose of the Study:

• To investigate the effects of double filtration plasmapheresis on systemic immune-inflammatory indices.
• To assess the potential of these indices as markers of inflammation and immunomodulation during apheresis.

Main Methods:

• Retrospective analysis of patients undergoing two double filtration plasmapheresis sessions.
• Measurement of complete blood count-derived immune-inflammatory indices and lipid profiles before and after sessions.
• Intra-individual comparisons using the Wilcoxon signed-rank test.

Main Results:

• Double filtration plasmapheresis significantly reduced neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammatory index, and aggregate index of systemic inflammation.
• Lymphocyte-to-monocyte ratio significantly increased; lipid profiles (total cholesterol, LDL, HDL, triglycerides, lipoprotein(a)) were also reduced.
• No significant change was observed in the systemic inflammation response index.

Conclusions:

• Double filtration plasmapheresis modulates short-term systemic immune-inflammatory indices beyond its lipid-lowering effects.
• These indices may serve as surrogate markers for acute systemic inflammation and immunomodulation.
• Monitoring these readily available indices can aid personalized patient assessment and care, particularly in inflammatory conditions.